Manipulating cardiac contractility in heart failure: data from mice and men.
نویسندگان
چکیده
Manipulating Cardiac Contractility in Heart Failure : Data From Mice and Men Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2004 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.0000111581.15521.F5 2004;109:150-158 Circulation. http://circ.ahajournals.org/content/109/2/150 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Integrative Physiology Protein Kinase C , but Not PKC or PKC , Regulates Contractility and Heart Failure Susceptibility Implications for Ruboxistaurin as a Novel Therapeutic Approach
Protein kinase (PK)C , PKC , and PKC comprise the conventional PKC isoform subfamily, which is thought to regulate cardiac disease responsiveness. Indeed, mice lacking the gene for PKC show enhanced cardiac contractility and reduced susceptibility to heart failure. Recent data also suggest that inhibition of conventional PKC isoforms with Ro-32-0432 or Ro-31-8220 enhances heart function and ant...
متن کاملThe Role of Nitric Oxide and Prostaglandins in the Effect of Adenosine on Contractility, Heart Rate and Coronary Blood Flow in Guinea Pig Isolated Heart
It is a well-established fact that adenosine and its receptor subtypes (A 1 and A ) are involved in changes of contractility, heart rate and coronary blood flow (CBF) under different circumstances. This study was conducted to evaluate the role of nitric oxide and prostaglandins in development of these changes. For this purpose, Nitro-L-Arginine methyl ester (L-NAME), and indomethacin as inhibit...
متن کاملتأثیر هشت هفته تمرین تناوبی خیلی شدید بر بیان ژن خانواده miR-29 و هایپرتروفی عضلهی قلبی رتهای نر سالم
Background and Objective: In this study the effect of high intensity interval training on miR-29 expression that is expressed in the heart and in the regulation of physiological processes, including extracellular matrix and cardiac hypertrophy of healthy male rats were examined. Materials and Methods: 16 Wistar rats were divided into training (n=8) and control (n=8) groups. After one week of fa...
متن کاملInhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury.
RATIONALE Protein kinase Cα (PKCα) activity and protein level are induced during cardiac disease where it controls myocardial contractility and propensity to heart failure in mice and rats. For example, mice lacking the gene for PKCα have enhanced cardiac contractility and reduced susceptibility to heart failure after long-term pressure overload or after myocardial infarction injury. Pharmacolo...
متن کاملShort Communication Inhibition of PKC / With Ruboxistaurin Antagonizes Heart Failure in Pigs After Myocardial Infarction Injury
Rationale: Protein kinase C (PKC ) activity and protein level are induced during cardiac disease where it controls myocardial contractility and propensity to heart failure in mice and rats. For example, mice lacking the gene for PKC have enhanced cardiac contractility and reduced susceptibility to heart failure after long-term pressure overload or after myocardial infarction injury. Pharmacolog...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Circulation
دوره 109 2 شماره
صفحات -
تاریخ انتشار 2004